Korean J Dermatol.  1988 Oct;26(5):708-713.

A Case of Chronic Bullous Dermatosis of Childhood

• Rhee JK
• Kang SB
• Cho BK
• Houh W

Abstract

We report a case of chronic bullous dermatosis of childhood occurring in a 8-year-old girl, who has multiple, pruritic, tense, vesicobullous eruptions on the both extremities and pelvic region without mucous membrane inuolvement. A skin biopsy revealed subepidermal vesicles infiltrated with many neutrophiles and a few eosinophiles. Direct immunofluorescent study of the perilesional skin demonstrated moderate intensity of linear IgA and to a lesser degree of IgG deposition at the dermoepidermal junction. The skin lesions responded dramatically to oral dapsone therapy, initially 4mg/kg, and taporing to 2mg/kg for 27 days.

Keyword

Chronic bullous dermatosis of childhood; Dapsone

MeSH Terms

Biopsy
Child
Dapsone
Eosinophils
Extremities
Female
Humans
Immunoglobulin A
Immunoglobulin G
Mucous Membrane
Neutrophils
Pelvis
Skin
Skin Diseases*
Transcutaneous Electric Nerve Stimulation
Dapsone
Immunoglobulin A
Immunoglobulin G