Korean J Dermatol.  1994 Jun;32(3):477-482.

A Case of Chronic Bullous Dermatosis of Childhood

• No authors listed

Abstract

Chronic bullous disease of childhood is a rare autoimmune vesiculobullous disorder characteristically seen in infancy and early childhood, and associated with the presence of IgA bound in a homogeneous linear array along the dermoepidermal junction. A 9-year-old boy showed generalized wheal like eruptions and vesicles on the whole body without subjective symptoms. Histopathologic findings of an intact early blister showed a subepidermal vesicle containing many neutrophils and a few eosinophils. Direct immunofluorescent study of the perilesional skin demonstrated linear deposition of IgA and C3 at the dermoepidermal junctions. Indirect immunofluorescent study was negative. The HLA-B8 was negative. The skin lesions responded well to dapsone therapy, 50mg/day, for 2 weeks.

MeSH Terms

Blister
Child
Dapsone
Eosinophils
HLA-B8 Antigen
Humans
Immunoglobulin A
Linear IgA Bullous Dermatosis
Male
Neutrophils
Skin
Skin Diseases*
Dapsone
HLA-B8 Antigen
Immunoglobulin A