Korean J Dermatol.  1988 Oct;26(5):697-701.

A Case of Lichen Myxedematosus

• Lee KB
• Cho BK
• Houh W

Abstract

The patient was a 50 year old woman complaining of generalized multiple pruritic erythematous waxy papules on the face, chest, abdomen, both dorsum of hands and both knee joints areas. There was marked accentuation i>f the skin folds, and the thickened skin was freely movable. Histopathologic findings showed extensive proliferation of fibroblasts throughout the dermis associated with irregularly arranged bundles of collagen, In many areas, the colagen bundles were split up into individual fibers by much, which was confirmed by special stains. She showed clinical response to melphalan therapy, which had to be discontinued because of severe bone marrow depression after 7 weeks.

Keyword

Lichen myxedmatosus; Melphalan Scleomyxcclem

MeSH Terms

Abdomen
Bone Marrow
Collagen
Coloring Agents
Depression
Dermis
Female
Fibroblasts
Hand
Humans
Knee Joint
Lichens*
Melphalan
Middle Aged
Scleromyxedema*
Skin
Thorax
Collagen
Coloring Agents
Melphalan