Korean J Hematol.  2012 Jun;47(2):150-153. 10.5045/kjh.2012.47.2.150.

Successful treatment of disseminated interdigitating dendritic cell sarcoma with adriamycin, bleomycin, vinblastine, and dacarbazine chemotherapy

Affiliations
  • 1Department of Hemato-oncology, Korea University Medical Center, Anam Hospital, Seoul, Korea.
  • 2Department of Pathology, Korea University Medical Center, Anam Hospital, Seoul, Korea. iskim@korea.ac.kr

Abstract

Interdigitating dendritic cell sarcoma (IDCS) is a very rare and aggressive neoplasm that arises from antigen presenting cells. IDCS usually involves lymph nodes; however, extra-nodal involvement has also been reported. Because a consistent standard therapy for IDCS has not been established to date, we report a case of the successful treatment of disseminated IDCS using ABVD chemotherapy (doxorubicin, bleomycin, vinblastine, and dacarbazine). A 64-year-old man was diagnosed with IDCS on the basis of immunohistochemical findings of a biopsy specimen of the inferior nasal concha. Immunohistochemical staining showed a positive reaction for CD68, leukocyte common antigen, and S-100 protein, but a negative reaction for CD34, CD1a, and CD21. Imaging studies showed cervical and axillary lymphadenopathies, subcutaneous nodules, and a soft tissue lesion in the nasal cavity. Treatment with the ABVD regimen resulted in complete remission after 8 cycles of chemotherapy.

Keyword

IDCS; ABVD chemotherapy; Complete remission

MeSH Terms

Antigen-Presenting Cells
Antigens, CD45
Biopsy
Bleomycin
Dacarbazine
Dendritic Cell Sarcoma, Interdigitating
Dendritic Cells
Humans
Middle Aged
Nasal Cavity
S100 Proteins
Turbinates
Vinblastine
Antigens, CD45
Bleomycin
Dacarbazine
S100 Proteins
Vinblastine

Figure

  • Fig. 1 Histological features of the nasal cavity include diffuse infiltration of spindle cells, large pleomorphic cells, foamy histiocytes, and various inflammatory cells (A). Immunohistochemical staining shows a strong positive reaction for S-100 protein (B).

  • Fig. 2 Computed tomography (CT) scans show multiple lymphadenopathies in both axillae (A) and lymphadenopathies on both sides of the neck (B).

  • Fig. 3 CT scans after 8 cycles of ABVD (adriamycin, bleomycin, vinblastine, and dacarbazine) shows complete resolution of axillary lymphadenopathies (A) and cervical lymphadenopathies (B).


Cited by  1 articles

A Case of Disseminated Extranodal Interdigitating Dendritic Cell Sarcoma Arising from Parotid Gland
Young Hoon Park, Shin Il Kim, Suk Jin Choi, Joo Han Lim, Hyeon Gyu Yi, Moon Hee Lee, Chul Soo Kim
Kosin Med J. 2015;30(2):163-169.    doi: 10.7180/kmj.2015.30.2.163.


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