Korean J Hematol.  2006 Jun;41(2):124-128. 10.5045/kjh.2006.41.2.124.

A Case of Primary Hepatic B-cell Lymphoma of Mucosa-associated Lymphoid Tissue (MALT)-Type

• Kim SR
• Kang BJ
• Eum SW
• Kim DY
• Joo YH
• Chang SH
• Lee JH
• Lee YB

• KMID: 2083488
• DOI: http://doi.org/10.5045/kjh.2006.41.2.124

Abstract

Mucosa-associated lymphoid tissue (MALT) lymphoma is a low grade B cell lymphoma that, occurs in numerous sites including the stomach, ocular adnexa, thyroid, lung and breast; however, primary hepatic lymphoma is extremely rare. Only about 20 cases have been reported world wide. We recently experienced a case of primary hepatic B-cell lymphoma of the MALT type in a 63-year old female patient. She presented with abdominal pain. The CT, ultrasonogram and PET-CT showed a hepatic nodular mass. A biopsy specimen of the liver revealed MALT lymphoma. There was no evidence of the lymphoma in the extrahepatic lesion. She received segmentectomy of liver and was then treated with CVP (cyclophosphamide, vincristine and prednisolone) chemotherapy. She has been followed up for 6 months since the therapy, and she remains asymptomatic.

Keyword

Liver; Primary; MALT lymphoma

MeSH Terms

Abdominal Pain
B-Lymphocytes*
Biopsy
Breast
Drug Therapy
Female
Humans
Liver
Lung
Lymphoid Tissue*
Lymphoma
Lymphoma, B-Cell*
Lymphoma, B-Cell, Marginal Zone
Mastectomy, Segmental
Middle Aged
Stomach
Thyroid Gland
Ultrasonography
Vincristine
Vincristine

Figure

• 

  Fig. 1 Abdomen dynamic CT. A 3cm sized hepatic mass like lesion (arrow) at left lobe lateral segment of liver.

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  Fig. 2 PET-CT. Focal single uptake at lateral segment of left lobe of liver. Normal visualization of the physiologic uptake at the heart, urinary system, liver, spleen and bowels.

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  Fig. 3 The cut surface of the liver shows a 2.2×2.0cm-sized, relatively well-defined flesh-like lobulated solid mass. The remaining parenchyme shows micronodular cirrhotic change.

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  Fig. 4 Histologic findings of the liver mass shows diffuse infiltration of small cleaved lymphcytes (centrocyte like cell) admixed with plasma cells in widened portal tract (H-E, ×400).

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  Fig. 5 Histologic findings of the liver mass shows a discrete cluster of three atypical lymphocytes in bile duct (lymphoepithelial lesion) of MALT lymphoma (PAS, ×400).

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  Fig. 6 On immunohistochemical staining, the tumor cells show immunoreactivity for CD20 (×400).

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