Korean J Hematol.  2002 May;37(2):143-146.

Nonmyeloablative Stem Cell Transplantation in a Patient with Refractory Acute Myeolgeous Leukemia with Central Diabetes Insipidus

• Kim YS
• Kim I
• Park HM
• Lee MH
• Kim CS

Abstract

A 31-year-old man presented fatigue, polydipsia and polyuria. He was diagnosed as acute myelogenous leukemia (AML) FAB-M1, and a water deprivation test confirmed central diabetes insipidus (DI). A sella magnetic resonance imaging showed the thickening of pituitary stalk with contrast enhancement suggesting leukemic infiltration. He was treated with remission induction chemotherapy including cytosine arabinoside and idarubicin, and concurrent intrathecal methotrexate, cytosine arabinoside and hydrocortisone. But he was not achieved a remission. Reinduction chemotherapy was also failed to induce remission. He underwent a non-myeloablative allogeneic he matopoietic stem cell transplantation (NST) from HLA one antigen mismatched sibling donor for refractory AML. After transplantation, he had no evidence of leukemia and DI, He showed complete conversion of donor chimerism. By day 7 after NST, desmopressin (DDAVP) was no longer required and a follow-up at 9 months he has no evidence of relapse. We report a rare case recovered from diabetes insipidus associated with acute myelogenous leukemia after NST in Korea.

Keyword

Diabetes insipidus (DI); Acute myelogous leukemia (AML); Non-myeloablative stem cell transplantation (NST)

MeSH Terms

Adult
Chimerism
Cytarabine
Deamino Arginine Vasopressin
Diabetes Insipidus
Diabetes Insipidus, Neurogenic*
Drug Therapy
Fatigue
Follow-Up Studies
Humans
Hydrocortisone
Idarubicin
Korea
Leukemia*
Leukemia, Myeloid, Acute
Leukemic Infiltration
Magnetic Resonance Imaging
Methotrexate
Pituitary Gland
Polydipsia
Polyuria
Recurrence
Remission Induction
Siblings
Stem Cell Transplantation*
Stem Cells*
Tissue Donors
Water Deprivation
Cytarabine
Deamino Arginine Vasopressin
Hydrocortisone
Idarubicin
Methotrexate