Korean J Hematol.  2002 May;37(2):138-142.

Two Cases of Intravascular Lymphomatosis

Affiliations
  • 1Department of Internal Medicine, Samsung Medical Center, College of Medicine, Sungkyunkwan University, Korea. wskimsmc@smc.samsung.co.kr
  • 2Department of Pediatrics, Samsung Medical Center, College of Medicine, Sungkyunkwan University, Korea.
  • 3Department of Pathology, Samsung Medical Center, College of Medicine, Sungkyunkwan University, Korea.
  • 4Department of Internal Medicine, College of Medicine, Seoul National University, Seoul, Korea.

Abstract

Intravascular lymphomatosis is a rare lymphoma characterized by neoplastic proliferation of malignant cells within the lumen of small blood vessels, usually presenting in the central nervous system or on the skin. Intravascular lymphomatosis is manifested clinically by fever, dementia, cutaneous nodules or plaques, and occasionally, dyspnea. The diagnosis of intravascular lymphomatosis is difficult because of misleading clinical features mimiking vasculitis, infection, stroke, or other neoplasm. We report two cases of intravascular lymphomatosis pesented as fever and skin rash. Those are confirmed by involved tissue biopsy. All cases were treated by combination chemotherapy, but the response was not good. Infectious problems were complicated and disease were progressed.

Keyword

Intravascular lymphomatosis; Skin rash; Fever; Combination chemotherapy

MeSH Terms

Biopsy
Blood Vessels
Central Nervous System
Dementia
Diagnosis
Drug Therapy, Combination
Dyspnea
Exanthema
Fever
Lymphoma
Skin
Stroke
Vasculitis
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