Korean J Hematol.
2001 Feb;36(1):100-104.
Multiple Chromosomal Abnormalities Accompanying Disseminated Granulocytic Sarcoma in Recurrent Acute Myelogenous Leukemia [50,XY,+8,+10,del(15)(q13),+21,+22]
- Affiliations
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- 1Department of Internmal Medicine, Seoul Adventist Hospital, Seoul, Korea. oncology@unitel.co.kr
- 2Department of Clinical Pathology, Seoul Adventist Hospital, Seoul, Korea.
- 3Department of Anatomical Pathology, Seoul Adventist Hospital, Seoul, Korea.
Abstract
- It is known that acute myelogenous leukemia (AML) carries chromosomal abnormalities in 55-78% of patients, and that chromosomal abnormalities were associated with pathophysiology of disease, clinical feature, and it's prognosis. Granulocytic sarcoma occurring in 2~14% of AML is especially associated with t(8;21), is common to misdiagnose as malignant lymphoma, and has poor prognosis as survival of 5.4 months due to poor response to chemotherapy. Hereby we report a case of recurrent AML occurred as granulocytic sarcoma carring multiple chromosomal aberration without accompanying t(8;21).
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