Korean J Hepatobiliary Pancreat Surg.  1997 Aug;1(2):41-58.

PROGNOSTIC FACTORS OF HEPATOCELLULAR CARCINOMA AFTER CURATIVE HEPATIC RESECTION

• Lee KU
• Koh YT
• Kim KH
• Kim JJ
• Cho BS
• Suh KS
• Kim ST

Abstract

To further define the prognostic factors associated with long term survival of hepatocellular carcinoma, we retrospectively studied 371 patients with pathologically diagnosed hepatocellular carcinoma who underwent curative hepatic resection between 1991 and 1995. We included the 16 patients who underwent noncurative hepatic resection in calculating overall survival. The male to female ratio was 5.1 to 1 and their average age was 52.5 years. About 20 variables were subject to univariate and multivariate analysis and their survivals were calculated using the Kaplan-Meier method. 55.6% of (220 of 396) patients had liver cirrhosis and 73.2% of (290 of 396) patients were positive in HBsAg. Operative mortality and inhospital death rate were 1.5% and 0.8%, each and postoperative morbidity rate was 22.5%. The cumulative 1, 3 and 5 year survival rates including noncurative resected cases were 85.9%, 67.2% and 54.8%, respectively. The cumulative 1, 3 and 5 year survival rates of 371 curative resected cases were 87.3%, 68.7% and 56.4%, respectively. Disease free 1, 3, 5 year survival rates of 371 curative resected cases were 74.8%, 48.2% and 40.8%, respectively. The factors such as alpha- fetoprotein, Child's classification, prothrombin time, extent of liver resection, and number of tumor were statistically significant factors associated with cumulative survival.(p<0.05) And alpha-fetoprotein, total necrosis after TACE, viral hepatitis, and invasion of portal vein were significant factors associated with cumulative disease free survival. Only alpha-fetoprotein was associated significantly with cumulative survival and cumulative disease free survival. Length to the resection margin was not significantly associated with survival.

Keyword

Hepatocellular carcinoma; Prognostic factor; Hepatectomy; alpha-fetoprotein; Survival rate

MeSH Terms

alpha-Fetoproteins
Carcinoma, Hepatocellular*
Classification
Disease-Free Survival
Female
Fetal Proteins
Hepatectomy
Hepatitis
Hepatitis B Surface Antigens
Humans
Liver
Liver Cirrhosis
Male
Mortality
Multivariate Analysis
Necrosis
Portal Vein
Prothrombin Time
Retrospective Studies
Survival Rate
Fetal Proteins
Hepatitis B Surface Antigens
alpha-Fetoproteins