Korean J Med.  2005 Jan;68(1):83-88.

A Case Of Primary Gastric Choriocarcinoma Associated With Adenocarcinoma

• Lee SW
• Kim SJ
• Park SH
• Do YR
• Song HS

Abstract

Choriocarcinoma is a HCG-producing epithelial neoplasm derived from either trophoblastic or totipotential germ cells. It is a highly malignant tumor, which is rapidly invasive and widely metastatic, and in most cases develops within the uterus after a normal or abnormal gestation, including ectopic pregnancy. Non-gestational choriocarcinoma rarely occur as a primary neoplasm in the gonads or in the extragonadal midline locations such as mediastinum, retroperitoneum, and pineal gland. It also has been reported very rarely to arise in parenchymal organs such as the prostate, lung, breast, brain, liver, kidney, bladder, vagina, and gastrointestinal tract. A 58-year old man was admitted to our hospital with symptoms of tarry stool and epigastric discomfort. The endoscopic biopsy specimen initially revealed pooly differentiated carcinoma of stomach with regional lymph node metastasis. Patient underwent distal gastrectomy with Billroth II anastomosis. Choriocarcinoma of stomach with well differentiated tubular adenocarcinoma was diagnosed by the surgical biopsy specimen, and the serum level of beta-HCG was 2,775 mIU/mL.In three months after operation, the patient presented with pain on right upper quadrant abdomen, and the CT scan revealed multiple liver metastasis. Bleomycin, etoposide, and cisplatin (BEP) combination chemotherapy were administered, but he died three months after the initial diagnosis.

Keyword

Choriocarcinoma; Non-gestational

MeSH Terms

Abdomen
Adenocarcinoma*
Biopsy
Bleomycin
Brain
Breast
Choriocarcinoma*
Choriocarcinoma, Non-gestational
Cisplatin
Diagnosis
Drug Therapy, Combination
Etoposide
Female
Gastrectomy
Gastroenterostomy
Gastrointestinal Tract
Germ Cells
Gonads
Humans
Kidney
Liver
Lung
Lymph Nodes
Mediastinum
Middle Aged
Neoplasm Metastasis
Neoplasms, Glandular and Epithelial
Pineal Gland
Pregnancy
Pregnancy, Ectopic
Prostate
Stomach
Tomography, X-Ray Computed
Trophoblasts
Urinary Bladder
Uterus
Vagina
Bleomycin
Cisplatin
Etoposide