Korean J Med.  1998 Apr;54(4):542-545.

A Case of Digoxin-like Immunoreactive Substance(DLIS) Poisoning After Ingestion of Fried Water Toad (Bufo Stejnegeri Schmidt)

• Kwak HC
• Oh YL
• Kwon HJ
• Oh SJ
• Kim SG
• Kim KS
• Yoo HJ
• Won DJ
• Park JS

Abstract

Everybody knows that toads are not eatable because of their toxins. But water toads are very similar to frogs morphologically, so fried water toads are eaten by some people on occasion. It has been studied that the granular glands of the toads secrete toxins known as digoxin-like immunoreactive substances (DLIS) such as bufogenins and bufotoxins. DLIS have cross-reactivity with micro particle enzyme immunoassay for the quantitative mea surement of digoxin. We report a case of DLIS poisoning in 56-year-old male patient who showed vomiting, syn cope, and marked bradyarrhythmia with block (heart rate down to 29 beats per minute) after ingestion of the fried water toads (Bufo stejnegeri Schmidt).

Keyword

Water toad; Bufo stejnegeri Schmidt; Digoxin-like immunoreactive substance; Poisoning

MeSH Terms

Bradycardia
Digoxin
Eating*
Humans
Immunoenzyme Techniques
Male
Middle Aged
Poisoning*
Vomiting
Digoxin