Korean J Med.  1997 Dec;53(6):759-768.

Diagnostic Efficacy of Exercise Tc - 99m Tetrofosmin SPECT in Patients with Coronary Artery Disease

• Choi JY
• Hwang JY
• Hwang JH
• Lim HJ
• Park HS
• Cho YK
• Chae SC
• Jun JE
• Park WH
• Ahn BC
• Lee JT
• Lee KB

Abstract

OBJECTIVES
Tetrofosmin is a new Tc-99m labeled myocardial perfusion imaging agent that shows slow clearance from the myocardium and rapid clearance from background organs. The purpose of this study was to assess the ability of exercise Tc-99m tetrofosmin single photon emission computed tomography(SPECT) to identify and localize coronary artery disease.
METHODS
The study population consists of 49 patients with suspected coronary artery disease who underwent both exercise Tc-99m tetrofosmin SPECT and coronary angiography within 2 weeks. Using the one day imaging protocol, 7-10mCi of Tc-99m tetrofosmin was injected at rest and 4 hours later, 25 mCi of Tc-99m tetrofosmin was injected at peak exercise.
RESULTS
The sensitivity and specificity of exercise Tc-99m tetrofosmin SPECT was 94.9% and 60% for detection of coronary artery disease with luminal narrowing more than 50%, and 96.4% and 33.3% for detection of coronary artery disease with luminal narrowing more than 70%. The sensitivity of exercise Tc-99m tetrofosmin SPECT for detection of individual stenosed vessels(>or=50% and >or=70% coronary stenosis) was 79.2%, 100% for LAD, 55.6%, 55.6% for LCx and 85.0%, 92.9% for RCA and the specificity was 88.0%, 75.0% for LAD, 100%, 87.5% for LCx, 86.2%, 77.1% for RCA respectively.
CONCLUSION
Exercise Tc-99m tetrofosmin SPECT appears to be an feasible and useful noninvasive test for the diagnosis of coronary artery disease

Keyword

Tc - 99m tetrofosmin; SPECT; Coronary artery disease

MeSH Terms

Coronary Angiography
Coronary Artery Disease*
Coronary Vessels*
Diagnosis
Humans
Myocardial Perfusion Imaging
Myocardium
Phenobarbital
Sensitivity and Specificity
Tomography, Emission-Computed, Single-Photon*
Phenobarbital