Korean J Med.  1997 Jul;53(1):128-132.

A Case of Secondary Pulmonary Alveolar Proteinosis Accompanied by Acute Erythroleukemia

• Whang YW
• Choi BH
• Lee NH
• Kwon SH
• Jeong JI
• Park JW
• Jon HS
• Park KJ
• Park KH
• Lee KY
• Kim HC

Abstract

Pulmonary alveolar proteinosis is a rare disease, which hallmark is a dense accumulation of PAS positive phospholipid material within alveolar sac. Pulmonary alveolar proteinosis is classified as primary form of unknown etiology and secondary form associated with other diseases. We report a case of secondary pulmonary alveolar proteinosis associated with acute erythroleukemia. A C year old male patient complained of nonproductive cough and general weakness, and presented fine inspiratory crackles at both lower lung field. Chest radiographs and high resolution CT scans showd a lobular pattern of ground-grass opacity with interlobular septal thickening in the center field of the both lungs, Bone marrow aspiration and biopsy revealed acute erythroleukemia. Open lung biopsy revealed PAS positive eosinophilic granular material filled in alveoli. He was treated with TAD chemotherapy, but died from multiorgan failure with pneumonia 22days after chemotherapy.

Keyword

Secondary alveolar proteinosis; Acute erythroleukemia

MeSH Terms

Biopsy
Bone Marrow
Cough
Drug Therapy
Eosinophils
Humans
Leukemia, Erythroblastic, Acute*
Lung
Male
Pneumonia
Pulmonary Alveolar Proteinosis*
Radiography, Thoracic
Rare Diseases
Respiratory Sounds
Tomography, X-Ray Computed