Korean J Med.  1997 May;52(5):672-677.

A Case of Acute Typhlitis Complicating Drug-induced Agranulocytosis

• Jeong YS
• Bae HH
• Jang ID
• Lee JM
• Hur D
• Yoon MS
• Lee SR
• Hong YB
• Huh K
• Lee JM

Abstract

Increasingly aggressive chemotherapy regimens, advances in transplantation technology, and the acquired immunodeficiency syndrome have resulted in a growing number of immunocompromised patients. Infections are a major cause of morbidity and mortality in this population. One of the most ominous complications is the development of typhlitis in this immunocompromised patients. Treatment of this process is controversial, and no consensus has emerged. We report a case of typhlitis who complicated agranulocytosis after exposure to drugs to treat "flu" like illness and recovered completely after two operations of appendectomy and ileocolectomy. Reviewing articles and this case, the favorable outcome seemed to be related to following three factors recognition of the acute surgical abdomen by abdominal CT scan, a prompt return of normal circulating white cells by the use of Granulocyte Colony Stimulating Factor and discontinuation of causative drugs, and an appropriately timed surgical intervention.

Keyword

Typhlitis; Granulocyte colony stimulating factor

MeSH Terms

Abdomen
Acquired Immunodeficiency Syndrome
Agranulocytosis*
Appendectomy
Colony-Stimulating Factors
Consensus
Drug Therapy
Granulocytes
Immunocompromised Host
Mortality
Tomography, X-Ray Computed
Typhlitis*
Colony-Stimulating Factors