Korean J Nephrol.  2010 Jan;29(1):89-93.

A Case of Distal Renal Tubular Acidosis and Sjogren's Syndrome in a Patient with Autoimmune Thyroiditis

• An HR
• Bae SC
• Lee KB
• Lee YK
• Kim JK
• Park HC
• Ha SK
• Lee JE

Abstract

A 52-year old woman, who had hypothyroidism associated with autoimmune thyroiditis for 5 years, was hospitalized for tingling sensation and muscle weakness of both lower extremities. Her initial laboratory findings showed severe hypokalemia, metabolic acidosis, and high titer of thyroid autoimmune antibodies. She was diagnosed of distal renal tubular acidosis by bicarbonate loading test (FEHCO(3)(-) <3.0 %) and renal calcifications on pre-enhanced CT scan. Since she had other symptoms of xerostomia and xerophthalmia, primary Sjogren's syndrome was diagnosed by Schirmer test, salivary scan, and serologic findings. She was treated with potassium citrate, potassium chloride, and hydroxychlorquine. Four months later, she has remained well with those treatments. There were only a few case reports about distal renal tubular acidosis associated with Sjogren's syndrome and autoimmune thyroiditis. In Korea, there has not been any report of such cases. Therefore, we report a case of distal renal tubular acidosis and Sjogren's syndrome in a patient with autoimmune thyroiditis.

Keyword

Autoimmune thyroiditis; Renal tubular acidosis; Sjogren's syndrome

MeSH Terms

Acidosis
Acidosis, Renal Tubular
Antibodies
Female
Humans
Hypokalemia
Hypothyroidism
Korea
Lower Extremity
Muscle Weakness
Potassium Chloride
Potassium Citrate
Sensation
Sjogren's Syndrome
Thyroid Gland
Thyroiditis, Autoimmune
Xerophthalmia
Xerostomia
Antibodies
Potassium Chloride
Potassium Citrate