Korean J Nephrol.  2006 May;25(3):457-460.

A Case of Renal Infarction associated with Protein C and S Deficiency

• Yeo CD
• Hwang HJ
• Park SM
• Son SW
• Shin SJ
• Song HC
• Choi EJ
• Chang YS

Abstract

Renal infarction usually occurs in patients with atrial fibrillation, valvular heart disease, trauma, renal artery stenosis, atherosclerosis, vasculitis, and hypercoagulable state. Protein C or S deficiency is an uncommon condition among hypercoagulable states and manifests deep vein thrombosis, pulmonary thromboembolism, cerebrovascular accident. In this report, we present a case of renal infarction occurred in 36-year-old male without underlying diseases except a family history of thromboembolism. He was admitted to our hospital due to an abrupt and continuous left flank pain. He had no previous history of an arterial or venous thrombosis. Tomography and renal angiography showed a left renal artery occlusion. He was treated with heparin and warfarin therapy. In laboratory tests, Protein C antigen level and protein S activity was 51.80% (72-160%) and 48% (65-140%). Thus, we concluded that renal infarction was secondary to combined type 1 protein C deficiency and type 2 protein S deficiency.

Keyword

Infarction; Protein C; Protein S deficiency

MeSH Terms

Adult
Angiography
Atherosclerosis
Atrial Fibrillation
Flank Pain
Heart Valve Diseases
Heparin
Humans
Infarction*
Male
Protein C Deficiency
Protein C*
Protein S
Protein S Deficiency
Pulmonary Embolism
Renal Artery
Renal Artery Obstruction
Stroke
Thromboembolism
Vasculitis
Venous Thrombosis
Warfarin
Heparin
Protein C
Protein S
Warfarin