Korean J Nephrol.  2001 Nov;20(6):1026-1030.

A Case of Collapsing Glomerulopathy Discovered in End Stage Renal Disease(ESRD) with Normal Sized Kidney

• Lee JY
• Kim MG
• Seo YJ
• Yu KJ
• Yoon HD
• Lee IH
• Ahn KS
• Kim YJ

Abstract

Collapsing glomerulopathy is recently described as the disease which causes rapidly progressive renal failure. Clinically, the disease starts with constitutional symptoms, and then nephrotic syndrome with marked proteinuria and hypertension follows. Eventually the disease rapidly progresses to the ESRD within several weeks to months. Its typical renal biopsy findings are extensive glomerular capillary collapse, visceral epithelial cell hypertrophy and hyperplasia, and variable degree of tubulointerstitial inflammation. Such findings closely resemble those of HIV associated nephropathy(HIVAN) except endothelial inclusion body in HIVAN. Here we present, for the first time in Korea, a 16 yrs-old female patient with ESRD in a normal sized kidney. Nephrotic syndrome and hypertension were also accompanied. Serologically, she had no evidence of HIV infection. Though her symptom duration was somewhat shorter than that previously reported, her renal biopsy findings were those of collapsing glomerulopathy as previously described. Her renal function did not return to normal, and now she is on regular hemodialysis, waiting for renal transplantation.

Keyword

Collapsing glomerulopathy; Nephrotic syndrome; Hypertension; ESRD

MeSH Terms

Biopsy
Capillaries
Epithelial Cells
Female
HIV
HIV Infections
Humans
Hyperplasia
Hypertension
Hypertrophy
Inclusion Bodies
Inflammation
Kidney Failure, Chronic
Kidney Transplantation
Kidney*
Korea
Nephrotic Syndrome
Proteinuria
Renal Dialysis
Renal Insufficiency