Yeungnam Univ J Med.  2012 Dec;29(2):102-105. 10.12701/yujm.2012.29.2.102.

A Case of Idiopathic Collapsing Glomerulopathy Showing Aggravation on a Chronic Progressive Course

Affiliations
  • 1Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu, Korea. jwpark@med.yu.ac.kr
  • 2Department of Pathology, College of Medicine, Yeungnam University, Daegu, Korea.

Abstract

Collapsing glomerulopathy (CG) has become an important cause of end-stage renal disease (ESRD). First delineated from other proteinuric glomerular lesions in the 1980s, CG is now recognized as a common, distinct pattern of proliferative parenchymal injury that portends a rapid loss of renal function and poor responses to empirical therapy. The first cases in the literature trace back to human-immunodeficiency-virus (HIV)-negative patients who underwent biopsy in 1979. A 45-year-old male patient complained of hematuria and proteinuria eight years ago. He showed an abrupt serum creatinine increase from 1.75 to 2.65mg/dL in the last preceding months. Afterwards, his serum creatinine progressively increased up to 6.82mg/dL. Moreover, his 24 h urine protein level was determined to have reached 6,171 mg/day, as opposed to 670 mg/day a year earlier. Consequently, renal biopsy was performed, and its result showed collapsing glomerulopathy, compatible with the diagnosis. He has undergone continuous ambulatory peritoneal dialysis as renal replacement therapy. Thus, it is reported herein that a patient clinically diagnosed with chronic kidney disease eight years ago showed a sudden renal-function decrease and was clinicopathologically diagnosed with collapsing glomerulopathy based on the results of his renal biopsy.

Keyword

Focal segmental glomerulosclerosis

MeSH Terms

Biopsy
Creatinine
Glomerulosclerosis, Focal Segmental
Hematuria
Humans
Kidney Failure, Chronic
Male
Peritoneal Dialysis, Continuous Ambulatory
Proteinuria
Renal Insufficiency, Chronic
Renal Replacement Therapy
Creatinine
Full Text Links
  • YUJM
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr