Korean J Nosocomial Infect Control.  2015 Jun;20(1):7-18. 10.14192/kjnic.2015.20.1.7.

Emergence and Spread of OXA-48-Like Carbapenemase-Producing Enterobacteriaceae

• Song W
• Jeong SH
• Lee J
• Lee SS
• Lee K

• KMID: 2078885
• DOI: http://doi.org/10.14192/kjnic.2015.20.1.7

Abstract

Since 2001, ten more OXA-48 variants have been identified. Shewanella spp. has been thought to be the original host for OXA-48-like enzymes. These enzymes strongly hydrolyze penicillins and weakly hydrolyze carbapenems, with very weak activity against broad-spectrum cephalosporins. The OXA-48-like genes are always plasmid-borne and have been located in insertion sequences. OXA-48-like carbapenemases have been identified mainly from Turkey, North African countries, the Middle East, and India. Furthermore, the emergence and outbreak of OXA-48-like producers in Korea have been reported recently. Because some OXA-48-like-producing Enterobacteriaceae isolates do not exhibit resistance to broad-spectrum cephalosporins and only decreased susceptibility to carbapenems, their detection can be difficult. Adequate screening and detection methods are required to prevent and control the dissemination of OXA-48-like-producing Enterobacteriaceae.

Keyword

Class D carbapenemase; Enterobacteriaceae; OXA-48-like

MeSH Terms

Carbapenems
Cephalosporins
Enterobacteriaceae*
India
Korea
Mass Screening
Middle East
Penicillins
Shewanella
Turkey
Carbapenems
Cephalosporins
Penicillins

Figure

• 

  Fig. 1. Modified Hodge test (A) and carbapenemase inhibition test (B) results for the KPC-2-producing K. pneumoniae (1), OXA-232-producing K. pneumoniae (2), DHA-1-producing K. pneumoniae (3), and NDM-1-producing K. pneumoniae isolate (4) are shown. (1) The positive MHT, negative EDTA and positive PBA, suggesting KPC (class A) production. (2) The positive MHT, negative EDTA and negative PBA, suggesting OXA (class D) production. (3) The negative MHT, negative EDTA and positive PBA, suggesting AmpC (class C) production. (4) The weak-positive MHT, positive EDTA and negative PBA, suggesting metallo-β-lactamase (class B) production. Abbreviations: ETP, ertapenem; MEM, meropenem; PBA, phenylboronic acid.

Reference

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