Korean J Nucl Med.  1998 Jun;32(3):250-258.

Safety and Feasibility of Thallium-201 Myocardial SPECT with Intravenous Infusion of Disodium Sdenosine Trophosphate ( ATP ) in the Diagnosis of Coronary Artery disease

• Pai MS
• Park CH
• Nam S
• Kim YW
• Kim HS

Abstract

PURPOSE: ATP (adenosine triphosphate) is a potent coronary vasodilator with a rapid onset of action and a very short half-life. Myocardial perfusion scintigraphy with intravenous ATP has not yet been sufficiently proven in the diagnosis, follow-up, and risk stratification of coronary artery disease. The purpose of this study was to evaluate the safety, feasibility and diagnostic accuracy of pharmacologic stress thallium-201 myocardial SPECT using an intravenous ATP infusion in patients with suspected coronary artery disease.
MATERIALS AND METHODS
Thalliurn-201 myocardial SPECT in 319 patients with suspected coronary artery disease were performed after the infusion of ATP (0.08 mg/kg/min for 6 rnin). The adverse effects were carefully monitored. Coronary angiography was also performed within 3 weeks.
RESULTS
Although 76.5% of the patients had sorne adverse effects, they were transient, mild, and well tolerated. In all patients, the ATP infusion protocol was completed and only 2 patients required aminophylline. The adverse effects were dyspnea in 63%, headache in 31%, flushing in 21%, chest pain in 14% and abdominal discomfort in 5% of the patients. The sensitivity and specificity were 80% and 90% respectively.
CONCLUSION
Thallium-201 myocardial SPECT after 6 min-infusion of ATP at a rate of 0.08 mg/kg/min is safe and has a diagnostic value in detecting coronary artery disease.

Keyword

thallium-201; disodium adenosine triphosphate; coronary artery disease

MeSH Terms

Adenosine Triphosphate*
Aminophylline
Chest Pain
Coronary Angiography
Coronary Artery Disease*
Coronary Vessels*
Diagnosis*
Dyspnea
Flushing
Follow-Up Studies
Half-Life
Headache
Humans
Infusions, Intravenous*
Perfusion Imaging
Sensitivity and Specificity
Tomography, Emission-Computed, Single-Photon*
Adenosine Triphosphate
Aminophylline