Korean J Obstet Gynecol.  2010 Jan;53(1):75-79. 10.5468/kjog.2010.53.1.75.

High malignant female adnexal tumor of probable wolffian origin (FATWO): A case report

• Lee JE
• Kwon YS
• Koo YJ
• Hong SR

• KMID: 2077964
• DOI: http://doi.org/10.5468/kjog.2010.53.1.75

Abstract

Female adnexal tumors of probable Wolffian origin (FATWO) are rare. Although the histological features of the benign tumors are recognized, features of malignancy are not well defined in published work because these tumors are particularly rare. In this study, we report a 52-year-old woman with a High malignant FATWO. The frozen biopsy of the fragile uterine mass, located at the left broad ligament, revealed a malignant FATWO with high mitotic figure (up to 36/10 HPF). The patient underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy, omentectomy, and paraaortic and pelvic lymph node dissection. Pathologic findings were consistent with malignant FATWO infiltrating to the unilateral salpinx without lymph node metastasis. The patient received three cycles of adjuvant treatment with paclitaxel and carboplatin. There was no clinical evidence of recurrence during the 12 months of follow-up; the patient is currently still being followed-up.

Keyword

Malignant; Female adnexal tumor; Wolffian origin

MeSH Terms

Adenoma
Adnexal Diseases
Biopsy
Broad Ligament
Carboplatin
Fallopian Tubes
Female
Humans
Hysterectomy
Lymph Node Excision
Lymph Nodes
Middle Aged
Neoplasm Metastasis
Paclitaxel
Recurrence
Adenoma
Adnexal Diseases
Carboplatin
Paclitaxel

Figure

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  Figure 1 Gross finding. A well demarcated mass, 12 cm in diameter, showing soft, solid yellow-tan mass with focal hemorrhage.

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  Figure 2 Microscopic finding. Low-power view showing closely packed variable sized hollow tubules lined by cuboidal epithelial cells (A), sieve-like pattern (B), cord-like arrangement (C), and solid growth (D). Hematoxylin and eosin ×40.

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  Figure 3 Immunohistochemical finding. Tumor cells having regular oval nuclei with dispersed chromatin, occasionally conspicuous nucleoli, and frequent mitoses (arrows), and showing positive reaction for CD10 which is supportive finding of probable Wolffian origin tumor.

Reference

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