Korean J Obstet Gynecol.  2003 Oct;46(10):2005-2012.

A Study for the Prevalence of High-risk HPV Subtype in Uterine Cervical Neoplasia of Korean Women

Affiliations
  • 1Department of Obstetrics and Gynecology, College of Medicine, Soonchunhyang Chunan Hospital, Soonchunhyang University, Chunan, Korea.
  • 2Department of Pathology, College of Medicine, Soonchunhyang Chunan Hospital, Soonchunhyang University, Chunan, Korea.

Abstract


OBJECTIVE
Many studies about Human Papilloma virus (HPV) that is a causative factor uterine cervical cancer have been established and more than 85 HPV types have been identified. The distributions of cancer-associated HPV types are different according to nations and region. To estimate the extent of infection with common HPVs among Korean women, we have examined specimens of various cervical lesion.
METHODS
The samples were collected from 135 Korean women visiting the Department of Obstetrics and Gynecology, Chunan Hospital Soonchunhyang University, Chunan, Korea. DNA was extracted from the specimen and 112 samples were available. HPV subtype were identified using HPV DNA Chip and P-E ABI prism 310 DNA Autosequencer.
RESULTS
HPV DNA was detected in 98 cervical sample (80.3%) out of 122 cases. HPV typing in the samples revealed the prevalence of HPV 16 in 56 cases (57.1%), followed by HPV 58 in 14 cases (14.3%) and HPV 18 were only 2 cases (2.0%) among 98 HPV (+) cases. HPV-negative case was 34.8% and HPV-positive case was 65.2% in CIN I group. HPV-negative case was significantly high in CIN I group. HPV-positive cases were 83 cases (83.8%) in the cases advanced more than CIN I. There were significant difference comparing CIN I group. The order of cervical neoplasia-associated type were HPV-16, -58, -52 and ect. The pattern is similar to the results reported in China and Japanese.
CONCLUSION
The finding indicated that the overall prevalence of HPV among Korean women is similar to that in China and Japanese, the distinct high proportion of HPV 58 infection deserves attention. The prevalence of high-risk HPV in Korean women is different from the one in western women but accumulated data from larger population and different regions in Korea is needed.

Keyword

Cervical neoplasia; HPV types; HPV DNA chip; Infection; Prevalence

MeSH Terms

Asian Continental Ancestry Group
China
Chungcheongnam-do
DNA
Female
Gynecology
Human papillomavirus 16
Human papillomavirus 18
Humans
Korea
Obstetrics
Oligonucleotide Array Sequence Analysis
Papilloma
Prevalence*
Uterine Cervical Neoplasms
DNA
Full Text Links
  • KJOG
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr