Korean J Obstet Gynecol.  2003 Mar;46(3):651-657.

A Novel Antiapoptosis Inhibitor, Survivin is Expressed in Uterine Cervical Cancer: The Relationship with prognostic Factors

• Lee JP
• Park YH
• Kim YS
• Han JH
• Chang KH
• Ryu HS

Abstract

OBJECTIVE
A novel inhibitor of apoptosis, survivin, seems to be involved in critical steps of cancer onset and progression, and associated with unfavorable clinical outcome. We investigated the expression of survivin in patients with cervical intraepithelial neoplasm and uterine cervical cancer to determine whether survivin indicates the poor prognosis or not.
METHODS
The study included 14 cases of cervical intraepithelial neoplasia grade III, 53 cases of invasive uterine cervical squamous cell carcinoma. Immunohistochemical stain and western blot was performed with antihuman survivin antibody.
RESULTS
Survivin was highly expressed in CIN III and cervical cancer group than normal control group (p<0.05). Significant survivin expression was noted in cancer patients with lesion size >or=4 cm, lymphovascular invasion, elevated SCC Ag. level, and nonresponse to initial therapy. As the clinical stage goes up, survivin expression had a tendency to increase but there was no statistical significance (p=0.081). No association was noted between survivin expression and survival rate (p=0.1011).
CONCLUSION
This results suggest that survivin expression may provide prognostic information and could represent a possible new marker of prognosis in uterine cervical squamous cell carcinoma patients.

Keyword

Survivin; Uterine cervical cancer; Apoptosis

MeSH Terms

Apoptosis
Blotting, Western
Carcinoma, Squamous Cell
Cervical Intraepithelial Neoplasia
Humans
Prognosis
Survival Rate
Uterine Cervical Neoplasms*