Korean J Obstet Gynecol.  2001 Nov;44(11):2104-2108.

Thermolabile Methylenetetrahydrofolate Reductase Gene Variants in Korean Women with Severe Preeclampsia

• Ji IW
• Jeong EH
• Kim HS
• Kim YB
• Rho JS
• Hong SH
• Kim JK
• Cho MC

Abstract

OBJECTIVE
This study was performed to evaluate C to T substitution at nucleotide 677 of meth-ylenetetrahydrofolate reductase gene in Korean women, which is genetically homogeneous, with preeclamptic or normotensive pregnancies.
METHODS
Methylenetetrahydrofolate reductase genotypes were determined in 63 Korean women with severe preeclamptic pregnancies and 60 controls with normotensive pregnancies, using polymerase chain reaction and restriction enzyme analysis.
RESULTS
The methylentetrahydrofolate reductase genotype and allele frequencies in preeclamptic and control women did not differ significantly. The frequency of the T677 allele was 38.1% in the preeclamptic group and 41.7% in the control group, and TT homozygosity was found in 12 preeclamptic women (19.0%) and 10 controls (16.7%).
CONCLUSION
It seems like that there is no evidence of association of preeclampsia with meth-ylenetetrahydrofolate reductase gene polymorphism, at least in the Korean population.

Keyword

Preeclampsia; Methylenetetrahydrofolate reductase; Polymorphism

MeSH Terms

Alleles
Female
Gene Frequency
Genotype
Humans
Methylenetetrahydrofolate Reductase (NADPH2)*
Oxidoreductases
Polymerase Chain Reaction
Pre-Eclampsia*
Pregnancy
Restriction Mapping
Methylenetetrahydrofolate Reductase (NADPH2)
Oxidoreductases