Clinical study in pregnant woman with Systemic Lupus Erythematosus

Han, S H; Lee, H J; Cho, H G; Kim, J S; Jang, B W; Byeun, T S; Shin, J W; Ro, D Y; Shin, J C; Kim, D K; Kim, S P

Abstract

OBJECTIVE
The purpose of this study was to evaluate the course of Systemic Lupus Erythematosus through hematologic change during pregnancy and the outcome of pregnancy in patients with SLE. Method: This retrospective study was done by the review of medical records of 25 pregnancies complicated with SLE in patients betwen Jan, 1989 and Dec, 1997. RESULTS: The common laboratory hematologic change in SLE with pregnant woman was elevated WBC count during peripartum period(p<0.05), significantly decreased during postpartum(p<0.05). And, during peripartum period ESR change was significantly elevated (p<0.05) but not obtained data during postpartum period. The serum level of C3 complement and C4 complement were not significantlty changed during peripartum and postpartum. So these factors are not affected by gestational condition. SLE pregnant woman's kidney function was relatively maintained during peripartum and postpartum according to BUN/Cr levels. Among 25 cases of SLE pregnant woman, there was 1 case of midtrimester termination due to spontaneous premature rupture of membranes (4 %), 5 cases of preterm birth (20 %), other were term delivery was done (19 cases, 76 %).
CONCLUSION
Our data suggest that the risk of pregnancy with SLE is not harmful to pregnant woman, especially hematologic indicies and not to bad in pregnant outcome of newborn baby in our cases.