A Study for Changes of blood clotting factor during Hormone Replacement Therapy of Postmenopausal woman

Lee, G; Jung, H

Abstract

OBJECTIVE
To evaluate the effect of HRT using estrogen combined with progesterone on the coagulation system. METHOD: A total of 60 patients who visited menopausal clinic of Obstetrics and Gynecology department at Chosun University Hospital were selected and divided into two groups, postmenopausal normal control group and study group. The control group was consisted of 30 patients, and the study group, 30 patients. Cyclic sequential hormone replacement therapy were given to study group patients, that is, administration of estrogen, estradiol valerate 2mg daily from first through 21st day of the month with addition of the progesteron, cyproterone acetate 1mg day for the last ten days of estrogen therapy from 12th through 21st day. The level of antithrombin III and clotting factor II, VII, IX, X were measured during the last 5days of medication. RESULT: 1. Antithrombin III level was 26.84[+/-2.73]mg/dl in control group, and 24.93[+/-2.44]mg/dl in study group. These difference were significant [p<0.05]. 2. Clotting factor II level was 89.73[+/-11.79]% in control group, and 110.36[+/-10.23]% in study group. These difference were significant [p<0.05]. 3. Clotting factor VII level was 113.80[+/-40.76]% in control group, and 134.36[+/-38.99]% in study group. These difference were significant [p<0.05]. 4. Clotting factor IX level was 109.53[+/-44.16]% in control group, and 124.40[+/-36.85]% in study group. These difference were not significant [p>0.05]. 5. Clotting factor X level was 87.20[+/-10.82]% in control group, and 105.06[+/-17.57]% in study group. These difference were significant [p<0.05].
CONCLUSION
HRT did affect antithrombin III, clotting factor II, VII, X level but HRT did not affect clotting factor IX. Antithrombin III, clotting factor II, VII, IX, X level were normal range.