Korean J Occup Environ Med.
2010 Dec;22(4):371-377.
The Brain Pathology on Recovery of Brain MRI after Manganese Administration in Rats
- Affiliations
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- 1Department of Occupational & Environmental Medicine, College of Medicine, Dong-A University, Korea. kimji@dau.ac.kr
- 2Department of Microbiology, College of Medicine, Dong-A University, Korea.
- 3Department of Radiology, College of Medicine, Dong-A University, Korea.
- 4Department of Pathology, College of Medicine, Dong-A University, Korea.
- 5Department of Family Medicine, College of Medicine, Dong-A University, Korea.
Abstract
OBJECTIVES
This study was carried out to investigate the effect on manganese on the brain of Sprague-Dawley rats, with particular focus on changes to anatomical pathology when brain MRI was recovered after manganese administration.
METHODS
There were 15 rats divided into 3 groups of 5 based on dose of manganese: control group, low dose group (10 mg/kg), and high dose group (40 mg/kg). Each dosing group received an injection of normal saline and manganese via the tail vein once a week for 4 weeks. And then, the rats were observed for 12 weeks after stopping manganese administration. Next, each rat underwent a brain MRI and then each was sacrificed. After the rats were killed, the concentrations of blood manganese were measured, and pathologic examinations of the brain were performed.
RESULTS
The signal intensity of basal ganglia on T1-weighted imaging of brain MRI did not differ between dosing groups. However, the ratio of neuron/glial cell in the basal ganglia was decreased in the low- and high-dose groups compared to the control group.
CONCLUSIONS
This study showed that the damage of neuron in basal ganglia might be permanent after signal intensity of basal ganglia on T1-weighted imaging of brain MRI was recovered.
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