Korean J Otolaryngol-Head Neck Surg.  1999 Feb;42(2):164-167.

The Protective Effects of Allopurinol, PAF Antagonist, LT Inhibitor, Superoxide Dismutase-Polyethylene Glycol, and Dexamethasone on Noise Induced Shift of Hearing Threshold in Guinea Pigs

• Jang YJ
• Hyun MH
• Hwang EJ
• Rhee CK

Abstract

BACKGROUND AND OBJECTIVES: Prevention of noise induced hearing loss (NIHL) can be achieved by environmental control, however, recently, there are some suggestions for the protective effects of various drugs. To find an effective drug on the protection of NIHL, we investigated the protective effects of allopurinol, platelet activating factor (PAF) antagonist, leukotriene (LT) inhibitor, superoxide dismutase-polyethylene glycol (SOD-PEG), and dexamethasone on the noise induced threshold shift in guinea pigs. MAERIALS AND METHODS: Thirty healthy guinea pigs (60 ears) were divided into control and different treatment groups to consist of five guinea pigs each. Guinea pigs were exposed to 100 dBA white noise for eight hours. Auditory Brainstem Response (ABR) were recorded before and after the noise exposure.
RESULTS
Changes in ABR thresholds were 48.1+/-9.6 dB SPL in the control group, 33.1+/-3.7 dB SPL in the allopurinol group, 39.37+/-17.8 dB SPL in the PAF antagonist group, 36.25+/-10.26 dB SPL in the LT inhibitor group, 38.0+/-13.98 dB SPL in the SOD-PEG group and 46.9+/-8.8 dB SPL in the dexamethasone group. Only the allopurinol group demonstrated significantly different threshold change compared to the control group.
CONCLUSION
The results of this study suggest that allopurinol may be effective in protection of noise induced threshold shift, whereas PAF antagonist, LT inhibitor, SOD, dexamethasone may not be as effective.

Keyword

Noise; Threshold shift; Protection

MeSH Terms

Allopurinol*
Animals
Dexamethasone*
Evoked Potentials, Auditory, Brain Stem
Guinea Pigs*
Guinea*
Hearing Loss
Hearing*
Noise*
Platelet Activating Factor
Superoxides*
Allopurinol
Dexamethasone
Platelet Activating Factor
Superoxides