Korean J Otorhinolaryngol-Head Neck Surg.  2009 Jul;52(7):566-571. 10.3342/kjorl-hns.2009.52.7.566.

Comparison of the Effect of High-Dose Steroid with That of Super-High-Dose Steroid Therapy in Sudden Sensorineural Hearing Loss

• Park HH
• Choi JH
• Huh EJ
• Lee TH
• Nam JK
• Kwon JK

• KMID: 2074134
• DOI: http://doi.org/10.3342/kjorl-hns.2009.52.7.566

Abstract

BACKGROUND AND OBJECTIVES: Corticosteroids have been used for therapeutic management of sudden sensorineural hearing loss (SSNHL). Because the levels of steroid within inner ear after systemic administration is very low, high-dose steroid regimens have been used. The purpose of this study is to compare the effect of high-dose (HD) steroid therapy with that of super-highdose (SHD) steroid therapy in SSNHL.
SUBJECTS AND METHOD
The study group consisted of 97 patients diagnosed as SSNHL. They were divided into two groups : those who were administered 60 mg prednisolone as the initial high dose (HD group) and those who were administered 1,200 mg hydrocortisone (about 300 mg prednisone) as the super high dose (SHD group).
RESULTS
Hearing improvement was observed in 76.8% of HD group and in 67.9% of SHD group and there was no statistically significant difference in the rate of hearing improvement between HD group and SHD group.
CONCLUSION
Super-high-dose steroid regimen is not superior to high-dose steroid regimen in the treatment of SSNHL.

Keyword

Sudden hearing loss; Steroids

MeSH Terms

Adrenal Cortex Hormones
Ear, Inner
Hearing
Hearing Loss, Sensorineural
Hearing Loss, Sudden
Humans
Hydrocortisone
Prednisolone
Steroids
Adrenal Cortex Hormones
Hydrocortisone
Prednisolone
Steroids