Korean J Pediatr Hematol Oncol.  1997 Apr;4(1):1-17.

Comprehensive Treatment of Advanced Neuroblastoma Using Autologous Bone Marrow Transplant at Nihon University

• Mugishima

Abstract

RESULTS
OF TREATMENT FOR ADVANCED NEUROBLASTOMA 1. The results of the comprehensive treatment of advanced NB using Auto-BMT in our hospital. We started a single protocol for the teatment of advanced neuroblastoma in January 1985. The induction chemotherapy, which is the Al protocol consisting of cyclophosphamide 1200mg/m2 given a as continuous infusion over 6 hours for 1 day, vincristin 1.5mg/m2 on day 1, THP-adriamycin which is a less cardiotoxic derivative of anthracycline developed in Japan 40mg/m2 on day 3 and cisplatin 90mg/m2 on day 5. This Al protocol was repeated every 4 weeks. Primary tumors and regional lymph node metastases were removed sometime during the first 5 or 6 cycles of the Al protocol.

MeSH Terms

Bone Marrow*
Cisplatin
Cyclophosphamide
Induction Chemotherapy
Japan
Lymph Nodes
Neoplasm Metastasis
Neuroblastoma*
Cisplatin
Cyclophosphamide