Korean J Perinatol.
2009 Dec;20(4):315-324.
Marternal Plasma ADMA Level, Placenta eNOS and Placenta Antioxidant Marker According to the Presence or Absence of Uterine Artery Notch on Color Doppler in the Third Trimester Pregnancies
- Affiliations
-
- 1Department of Obstetrics and Gynecology, School of Medicine, Ewha Womans University, Korea. kkyj@ewha.ac.kr
- 2Medical Research Institute, Ewha Global Challenge Center, Ewha Womans University, Seoul, Korea.
Abstract
- PURPOSE
We examined pregnancy outcomes and maternal plasma asymmetric dimethylarginine (ADMA) concentrations in the presence or absence of uterine artery notch, and analyzed their relationships to the expression of placental endothelial nitric oxide synthase (eNOS) and antioxidant enzymes, including manganese superoxide dismutase (MnSOD), glutathione peroxidase (GPX), and catalase.
METHODS
We assessed uterine artery doppler waveforms in 30 women who had been hospitalized for delivery. Plasma concentrations of ADMA were also measured. Tissue samples of placentas were obtained from 15 patients with diastolic notch and 15 patients without diastolic notch, according to uterine Doppler velocimetry analysis. We evaluated the placental expression of eNOS, MnSOD, GPX and catalase with Western blot analysis and eNOS with immunohistochemistry.
RESULTS
The maternal plasma ADMA concentration increased significantly in the group with bilateral Uterine artery notch compared with the group without uterine artery notch (P=0.04). The expression of eNOS in the placenta significantly increased and the expression of MnSOD and GPX decreased significantly in the group with uterine artery notch at the third trimester.
CONCLUSION
Uterine artery diastolic notch in pregnant women is associated with high maternal plasma ADMA, increased placental eNOS, and decreased MnSOD and GPX.
Keyword
MeSH Terms
-
Arginine
Blotting, Western
Catalase
Female
Glutathione Peroxidase
Humans
Nitric Oxide Synthase Type III
Placenta
Plasma
Pregnancy
Pregnancy Outcome
Pregnancy Trimester, Third
Pregnant Women
Rheology
Superoxide Dismutase
Uterine Artery
Arginine
Catalase
Glutathione Peroxidase
Nitric Oxide Synthase Type III
Superoxide Dismutase
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