Korean J Perinatol.
2005 Dec;16(4):322-326.
A Case of Lymphocytic Hypophysitis Occurred in the Second-trimester of Pregnancy
- Affiliations
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- 1Department of Obstetrics and Gynecology, College of Medicine Catholic University of Korea, Seoul, Korea. parktc@catholic.ac.kr
- 2Department of Pathology, College of Medicine Catholic University of Korea, Seoul, Korea.
- 3Department of Neurosurgery, College of Medicine Catholic University of Korea, Seoul, Korea.
Abstract
- Lymphocytic hypophysitis, a rare inflammatory disorder in the pituitary gland that is often associated with pregnancy, is caused by autoimmune destruction of the pituitary gland evidenced by diffuse lymphocytic infiltration in the pituitary gland. We report a case of lymphocytic hypophysitis in a 38-year-old woman presenting with aggravating headache and sudden visual loss during pregnancy, which was misdiagnosed as pituitary adenoma before neurosurgery. Magnetic resonance imaging, with enhancement, showed an expanding 2.5x2.0x1.7 cm sized sellar mass. The patient underwent transsphenoidal surgery with a preoperative diagnosis of pituitary macroadenoma. A histological examination revealed diffuse lymphocytes and fibrosis of adenohypophysis with atrophy, which are characteristic of lymphocytic hypophysitis. We report a case of lymphocytic hypophysitis occurred during pregnancy with a brief review of literatures.
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