Korean J Physiol Pharmacol.
2005 Dec;9(6):323-326.
Effects of Ambroxol, S-carboxymethylcysteine, Dextromethorphan and Noscapine on Mucin Release from Airway Goblet Cells
- Affiliations
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- 1Department of Pharmacology, College of Medicine, Chungnam National University, Daejeon 301-131, Korea. LCJ123@cnu.ac.kr
- 2Department of Thoracic Surgery, Chungnam National University Hospital, Daejeon 301-721, Korea.
- 3Department of Oriental Medicine, College of Oriental Medicine, Dongguk University, Gyeongju 780-714, Korea.
Abstract
- In the present study, we investigated whether ambroxol, S-carboxymethyl-L-cysteine, dextromethorphan and noscapine affect mucin release from airway goblet cells. Confluent primary hamster tracheal surface epithelial cells were metabolically radiolabeled and chased for 30 min in the presence of varying concentrations of the above agents to assess the effects on 3H-mucin release. Noscapine stimulated mucin release during 30 min of treatment period in a dose-dependent manner. However, ambroxol, S-carboxymethyl-L-cysteine and dextromethorphan showed no significant effect on mucin release during 30 min of treatment period. We conclude that noscapine can affect mucin release by acting on airway mucin-secreting cells.
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