Korean J Physiol Pharmacol.
2003 Jun;7(3):181-185.
Sympathetic Regulation of Aquaporin Water Channels in Rat Kidney
- Affiliations
-
- 1Department of Physiology, Chonnam National University Medical Schoo, Korea. julee@jnu.ac.kr
- 2Department of Physiology, Seonam University College of Medicine, Korea.
- 3Department of Pharmacology, Chosun University Medical College, Gwangju, Korea.
Abstract
- Whether there exists a sympathetic neural regulation on the aquaporin (AQP) channels in the kidney was examined. Male Sprague-Dawley rats were used. They were renal nerve denervated by stripping the nervous and connective tissues passing along the renal artery and vein, and painting these vessels with 10% phenol solution through a midline abdominal incision. Three days later, the expression of AQP1-4 proteins in the denervated kidneys was determined. The content of norepinephrine was found significantly decreased following the denervation. Accordingly, the expression of AQP2 proteins was markedly decreased. The expression of AQP3 and AQP4 was also slightly but significantly decreased, while that of AQP1 was not. Neither the basal nor the AVP-stimulated accumulation of cAMP was significantly affected in the denervated kidney. It is suggested that the sympathetic nervous system has a tonic stimulatory effect on AQP channels in the kidney.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Sympathetic and parasympathetic regulation of sodium transporters and water channels in rat submandibular gland
- Altered Renal Expression of Aquaporin-2 Water Channels in Two-Kidney, One Clip Hypertension in Rats
- Role of Nitric Oxide in the Regulation of Aquaporin-2 Water Channels in Rat Kidney
- Decreased expression of aquaporin-2 water channels in the kidney in rats treated with reserpine
- Autonomic Neural Regulation of Sodium Transporters and Water Channels in Rat Submandibular Gland
