Relationship between Metabolic Syndrome and Cognitive Functions in Patients with Chronic Schizophrenia

Kim, Kyung Yoon; Kim, Shin Kyum; Byun, Won Tan; Lee, Duk Ki; Jung, Bong Joo; Park, Young Min; Seo, Jae Won

Abstract

OBJECTIVES
The aim of this study was to investigate the relationship between metabolic syndrome and cognitive functions among chronic schizophrenia patients.
METHODS
The survey participants were 105(40 metabolic syndrome and 65 non-metabolic syndrome) chronic schizophrenia patients at Yang-san Hospital. Each score of cognitive test(A Korean version of the Consortium to Establish a Registry for Alzheimer's Disease Assessment Packet, stroop test), Positive and Negative Syndrome Scale, Hamilton rating scale for Depression were assessed. Statistical analysis of the relationship between various tests of A Korean version of the Consortium to Establish a Registry for Alzheimer's Disease Assessment Packet and metabolic syndrome were performed using ANCOVA and logistic regression.
RESULTS
Schizophrenia patients with lower score on construction praxia were likely to be included in Metabolic syndrome group. However, there were no significant relationships in other tests between the two groups.
CONCLUSION
This study found metabolic syndrome caused cognitive decline in chronic schizophrenia patients, especially Construction praxia. This study could be a basis to show metabolic syndrome has to be treated appropriately in schizophrenia patients and suggests the necessity of following longitudinal designed study.