Korean J Parasitol.  2014 Dec;52(6):695-699. 10.3347/kjp.2014.52.6.695.

Chronic Opisthorchis viverrini Infection and Associated Hepatobiliary Disease Is Associated with Iron Loaded M2-like Macrophages

Affiliations
  • 1Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, USA. moses_bility@med.unc.edu
  • 2Department of Pathology, Khon Kaen University, Khon Kaen, Thailand.

Abstract

Chronic Opisthorchis viverrini-induced hepatobiliary disease is associated with significant leukocyte infiltration, including activated macrophages; however, the polarization of infiltrating macrophages remains to be fully characterized. In this study, we characterized macrophage polarization and phenotype in chronic O. viverrini-induced hepatobiliary disease in humans and hamsters using gene expression and histochemical analysis. Chronic O. viverrini infection and associated hepatobiliary diseases were associated with iron loaded M2-like macrophages in both humans and hamsters. This study provides suggestive evidence that iron loaded M2-like macrophages promote hepatobiliary disease in chronic O. viverrini infection.

Keyword

Opisthorchis viverrini; M2-like macrophage; iron; hepatobiliary fibrosis; cancer

MeSH Terms

Animals
Cricetinae
Gene Expression Profiling
Histocytochemistry
Humans
Immunohistochemistry
Iron/*metabolism
Liver Cirrhosis/*parasitology/*pathology
Macrophages/*immunology/metabolism
Mesocricetus
Opisthorchiasis/*complications/*pathology
Opisthorchis/*isolation & purification
Iron
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