Korean J Parasitol.
2014 Dec;52(6):695-699. 10.3347/kjp.2014.52.6.695.
Chronic Opisthorchis viverrini Infection and Associated Hepatobiliary Disease Is Associated with Iron Loaded M2-like Macrophages
- Affiliations
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- 1Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, USA. moses_bility@med.unc.edu
- 2Department of Pathology, Khon Kaen University, Khon Kaen, Thailand.
- KMID: 2069824
- DOI: http://doi.org/10.3347/kjp.2014.52.6.695
Abstract
- Chronic Opisthorchis viverrini-induced hepatobiliary disease is associated with significant leukocyte infiltration, including activated macrophages; however, the polarization of infiltrating macrophages remains to be fully characterized. In this study, we characterized macrophage polarization and phenotype in chronic O. viverrini-induced hepatobiliary disease in humans and hamsters using gene expression and histochemical analysis. Chronic O. viverrini infection and associated hepatobiliary diseases were associated with iron loaded M2-like macrophages in both humans and hamsters. This study provides suggestive evidence that iron loaded M2-like macrophages promote hepatobiliary disease in chronic O. viverrini infection.
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