Korean J Parasitol.
2021 Aug;59(4):363-368. 10.3347/kjp.2021.59.4.363.
Helicobacter pylori GroEL Seropositivity Is Associated with an Increased Risk of Opisthorchis viverrini-Associated Hepatobiliary Abnormalities and Cholangiocarcinoma
- Jala I1,2
- Almanfaluthi ML1,2
- Laha T3
- Kanthawong S4
- Tangkawattana S2,5
- Saichua P1,2
- Suttiprapa S
1,2 - Sripa B2,6
- Affiliations
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- 1Tropical Medicine Graduate Program (International Program), Academic Affairs, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
- 2WHO Collaborating Centre for Research and Control of Opisthorchiasis (Southeast Asian Liver Fluke Disease), Tropical Disease Research Centre, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
- 3Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
- 4Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
- 5Department of Pathobiology, Faculty of Veterinary Medicine, Khon Kaen University, Khon Kaen, Thailand
- 6Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
- KMID: 2519809
- DOI: http://doi.org/10.3347/kjp.2021.59.4.363
Abstract
- Despite the synergistic effect of Opisthorchis viverrini and Helicobacter pylori co-infection on pathogenesis of severe hepatobiliary abnormalities (HBA) including advanced periductal fibrosis and replace with cholangiocarcinoma (CCA) have been established, the immune response to H. pylori in O. viverrini infected population has never been explored. Hence, this study aimed to investigate the antibody responses to 2 immunogenic H. pylori proteins in O. viverrini-infected patients with HBA and CCA. The risk analysis by multinomial logistic regression revealed that GroEL seropositivity was associated with higher risks of hepatobiliary abnormalities and CCA with adjusted odds ratios (95% confidence intervals) of 2.11 (95% CI=1.20-3.71, P=0.008) and 2.13 (95% CI=1.21-3.75, P=0.009), respectively. These findings indicate that GroEL seropositivity might be a biomarker for early detection of O. viverrini associated HBA and CCA.
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