Korean J Obes.  2015 Sep;24(3):121-125. 10.7570/kjo.2015.24.3.121.

Obesity and Dysbiosis

• Kim SM

• KMID: 2068484
• DOI: http://doi.org/10.7570/kjo.2015.24.3.121

Abstract

Recent studies have described an association between obesity and gut microbiota, suggesting that the latter might play a critical role in the development of the former. Possible mechanisms by which gut microbiota can mediate obesity are by changes in gut microbiota which can influence energy absorption, modulate associated enzymes and induce low-grade inflammation. Several studies have reported beneficial effects of lactic acid bacteria (LAB), including anti-obesity effects and improvements in lipid profiles. However, other studies have reported of no beneficial effects of LAB on obesity, or even an increase in obesity. Using probiotics for the improvement of gut microbiota as a treatment for obesity is likely to be more complex than anticipated and may require a long-term complex program (e.g., 4R program: remove, replace, reinoculate, repair) and multiple follow-up evaluations over time.

Keyword

Gut microbiota; Obesity; Anti-obesity; 4R program

MeSH Terms

Absorption
Bacteria
Dysbiosis*
Follow-Up Studies
Inflammation
Lactic Acid
Microbiota
Obesity*
Probiotics
Lactic Acid