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The Effect of Curcumin on the Gut-Brain Axis: Therapeutic Implications

Enayati A, Soghi A, Butler AE, Rizzo M, Sahebkar A

  • KMID: 2546964
  • J Neurogastroenterol Motil.
  • 2023 Oct;29(4):409-418.
  • doi: 10.5056/jnm23065
The gut-brain axis describes the bidirectional communication between the gut, the enteric nervous system, and the central nervous system. The gut-brain axis has attracted increasing attention owing to its regulatory...
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Probiotic supplementation has sexdependent effects on immune responses in association with the gut microbiota in community-dwelling older adults: a randomized, double-blind, placebocontrolled, multicenter trial

Kim CS, Jung MH, Choi EY, Shin DM

BACKGROUND/OBJECTIVES: Probiotics have been suggested as potent modulators of agerelated disorders in immunological functions, yet little is known about sex-dependent effects of probiotic supplements. Therefore, we aimed to investigate sex-dependent...
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Gut microbiota and nonalcoholic fatty liver disease

Kim B, Kim B

The gut microbiota has been reported to exert a significant influence on various physiological responses of hosts. Extensive evidence has recently emerged linking metabolic and cardiovascular disorders to the gut...
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A ketogenic diet reduces body weight gain and alters insulin sensitivity and gut microbiota in a mouse model of diet-induced obesity

Heo S, Yang SJ

Purpose: Ketogenic diets (KDs) have anti-obesity effects that may be related to glucose control and the gut microbiota. This paper hypothesizes that KD reduces body weight and changes the insulin...
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Research progress and treatment of radiation enteritis and gut microbiota

Ren H, Wu Q, Sun Z, Fang M, Liu J, Luo J

Radiation enteritis is a kind of intestinal radiation injury in patients with pelvic and retroperitoneal malignancies after radiotherapy, and its occurrence and development process are very complicated. At present, studies...
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Gut Microbiota Dysbiosis Correlates With Long COVID-19 at One-Year After Discharge

Zhang D, Zhou Y, Ma Y, Chen P, Tang J, Yang B, Li H, Liang M, Xue Y, Liu Y, Zhang J, Wang X

Background: Long coronavirus disease 2019 (COVID-19) in recovered patients (RPs) is gradually recognized by more people. However, how long it will last and the underlining mechanism remains unclear. Methods: We conducted...
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Association of gut microbiota with obesity in children and adolescents

Cho KY

Pediatric obesity is among the most serious global health problems whose prevalence has increased over the past decade. Pediatric obesity increases concomitant health problems, including type 2 diabetes mellitus, hypertension,...
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Babeisa duncani infection alters gut microbiota profile in hamsters

The genus Babesia includes parasites that can induce human and animal babesiosis, which are common in tropical and subtropical regions of the world. The gut microbiota has not been examined...
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The Role of Gut Microbiota and Genetic Susceptibility in the Pathogenesis of Pancreatitis

Xu F, Yang C, Tang M, Wang M, Cheng Z, Chen D, Chen X, Liu K

Pancreatitis is one of the most common inflammatory diseases of the pancreas caused by autodigestion induced by excessive premature protease activation. However, recognition of novel pathophysiological mechanisms remains a still...
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Interaction between Dietary Factors and Gut Microbiota in Ulcerative Colitis

Sung MK

Ulcerative colitis (UC) exhibits chronic intestinal inflammatory conditions with cycles of relapse and remission. The incidence is rapidly growing in Asian countries including South Korea possibly due to changes in...
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Chemopreventive Effect of Metformin on Gastric Cancer Development

Cheung KS, Chung KL, Leung WK

Although Helicobacter pylori infection is the most important causative factor for gastric cancer (GC), H. pylori eradication alone does not completely eliminate the GC risk. In addition to H. pylori...
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From the Dish to the Real World: Modeling Interactions between the Gut and Microorganisms in Gut Organoids by Tailoring the Gut Milieu

Park NY, Koh A

The advent of human intestinal organoid systems has revolutionized the way we understand the interactions between the human gut and microorganisms given the host tropism of human microorganisms. The gut...
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Aging effects on the diurnal patterns of gut microbial composition in male and female mice

Kim HJ, Moon CM, Kang JL, Park EM

Composition of the gut microbiota changes with aging and plays an important role in age-associated disease such as metabolic syndrome, cancer, and neurodegeneration. The gut microbiota composition oscillates through the...
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The effect of probiotics supplementation in postoperative cancer patients: a prospective pilot study

Kwon H, Chae SH, Jung HJ, Shin HM, Ban OH, Yang J, Kim JH, Jeong JE, Jeon HM, Kang YW, Park CK, David Won D, Lee JK

Purpose: Microbiota manipulation through selected probiotics may be a promising tool to prevent cancer development as well as onset, to improve clinical efficacy for cancer treatments. The purpose of this...
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Dietary modulation of gut microbiota for the relief of irritable bowel syndrome

Kim MY, Choi SW

Irritable bowel syndrome (IBS) is a frequently diagnosed gastrointestinal (GI) disorder characterized by recurrent abdominal pain, bloating, and changes in the stool form or frequency without any structural changes and...
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Effect of gut microbiome on minor complications after a colonoscopy

Kim JH, Choi YJ, Kwon HJ, Jung K, Kim SE, Moon W, Park MI, Park SJ

Background/Aims: Minor complications that might occur after colonoscopy, including abdominal discomfort, bloating, diarrhea, and constipation, could a barrier for patients to undergo a screening colonoscopy. In this study, we aimed...
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Modulation of Pro-inflammatory and Anti-inflammatory Cytokines in the Fat by an Aloe Gel-based Formula, QDMC, Is Correlated with Altered Gut Microbiota

An J, Lee H, Lee S, Song Y, Kim J, Park IH, Kong H, Kim K

Abnormal inflammatory responses are closely associated with intestinal microbial dysbiosis. Oral administration of Qmatrix-diabetes-mellitus complex (QDMC), an Aloe gel-based formula, has been reported to improve inflammation in type 2 diabetic...
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Dysregulated Free Fatty Acid Receptor 2 Exacerbates Colonic Adenoma Formation in ApcMin/+ Mice: Relation to Metabolism and Gut Microbiota Composition

Huang YW, Lin CW, Pan P, Echeveste CE, Dong A, Oshima K, Yearsley M, Yu J, Wang LS

Free fatty acid receptor 2 (FFAR2) has been reported as a tumor suppressor in colon cancer development. The current study investigated the effects of FFAR2 signaling on energy metabolism and...
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Regulation of Gut Microbiota Disrupts the Glucocorticoid Receptor Pathway and Inflammation-related Pathways in the Mouse Hippocampus

Rao X, Liu L, Wang H, Yu Y, Li W, Chai T, Zhou W, Ji P, Song J, Wei H, Xie P

An increasing number of studies have recently indicated the important effects of gut microbes on various functions of the central nervous system. However, the underlying mechanisms by which gut microbiota regulate...
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Nonalcoholic fatty liver disease and alcohol-related liver disease: From clinical aspects to pathophysiological insights

Ikejima K, Kon K, Yamashina S

Two major causes of steatohepatitis are alcohol and metabolic syndrome. Although the underlying causes of alcoholrelated liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH) differ, there are...
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