J Korean Neurosurg Soc.  1987 Mar;16(1):247-254.

An Experiments Study for Usage of Urokinase in Treatment of Intracerebral Hematoma

• Lee CR
• Hwang SS
• Park DS
• Kim SC

Abstract

Thrombolysis using urokinase solution is one of the effective methods in treatment of intracerebral hematoma. The present study was undertaken in order to 1) determine the most effective concentration of urokinase solution, 2) determine the most suitable time interval of irrigation of urokinase solution through the measurement of hemoglobin and FDP(Fibrin / Fibrinogen Degradation Product) of drained solution, 3) estimate the size of unresolved hematoma without taking brain CT. The results are summarized as follows : 1) The most effective and economic concentration of urokinase solution was 1000 u/ml. 2) The most preferable time interval of irrigation of urokinase solution was about one hour. 3) It was possible to estimate the size of unresolving hematoma by means of measurement of hemoglobin and hematocrit of patient, hemoglobin and volume of the thrombolysed solution, so that it was unnecessary to take brain CT for measurement of remaining hematoma.

Keyword

Intracerebral hematoma; Urokinase; Hemoglobin; FDP(Fibrin/Fibrinogen Degradation Product); Thrombolysis

MeSH Terms

Brain
Fibrinogen
Hematocrit
Hematoma*
Humans
Urokinase-Type Plasminogen Activator*
Fibrinogen
Urokinase-Type Plasminogen Activator