J Korean Neurol Assoc.
1995 Dec;13(4):1007-1010.
A Case of Diffuse Leukoencephalopathy Caused by 5-Fluorouracil
- Affiliations
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- 1Department of Neurology, Taejon, Eulji Hospital, Korea.
Abstract
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5-Fluorouracil is one of the most commonly used anticancer drug. We report a case of leukoencephalopathy who had received 5-fluorouracil injection following operation of carcinoid tumor in intestine. The case had dementia, dysarthria and gait disturbance. Brain CT showed bilaterally symmetric diffuse low densities in the white matter of cerebrum and cytologic examination of cerebrospinal fluid was negative for malignancy. Discontinuation of 5- fluorouracil injection for several days and then improved the clinical symptoms.