J Korean Endocr Soc.  2008 Apr;23(2):142-147. 10.3803/jkes.2008.23.2.142.

A Case of Lymphocytic Infundibuloneurohypophysitis Along with Central Diabetes Insipidus, and this Improved with Conservative Care

• Lee JM
• Park SM
• Hwang BH
• Choi HS
• Lee SS
• Kim JY
• Kim SR
• Lee KW
• Son HY
• Kang SK
• Yoo SJ

• KMID: 2063566
• DOI: http://doi.org/10.3803/jkes.2008.23.2.142

Abstract

Idiopathic central diabetes insipidus is most likely to occur in young patients who have a clinical history of autoimmune disease. The presentation of clinical findings such as central diabetes insipidus and pituitary stalk thickening on sellar magnetic resonance imaging (MRI) in a young women would strongly suggest lymphocytic hypophysitis, which is a rare inflammatory process involving the pituitary stalk and the pituitary gland, yet this disease can sometimes regress.

Keyword

idiopathic central diabetes insipidus; lymphocytic hypophysitis; young fertile women

MeSH Terms

Autoimmune Diseases
Diabetes Insipidus, Neurogenic
Female
Humans
Magnetic Resonance Imaging
Pituitary Gland

Figure

• 

  Fig. 1 Sellar MRI at admission. The normal posterior 'bright spot' on T1 weighted image is lost and pituitary gland is enlarged. Pituitary stalk is thickened with marked contrast enhancement.

• 

  Fig. 2 Sellar MRI after 45 days later. Previous Pituitary enlargement and Pituitary Stalk thickening was regressed 6.6 mm to 4.6 mm.

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  Fig. 3 Sellar MRI after 6 months later. Previous Pituitary enlargement and Pituitary Stalk thickening was more regressed 4.6 mm to 4.29 mm.

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