J Korean Diabetes Assoc.  2006 Mar;30(2):130-135. 10.4093/jkda.2006.30.2.130.

A Case of Chronic Inflammatory Demyelinating Polyneuropathy in a Girl with Type 1 DM

• Jang YS
• Kim HS
• Lee JM

• KMID: 2063442
• DOI: http://doi.org/10.4093/jkda.2006.30.2.130

Abstract

Chronic inflammatory demyelinating polyneuropathy (CIDP) is an immune-mediated disorder characterized by the symmetrical weakness in both proximal and distal muscles for at least 2 months, hyporeflexia or areflexia, nerve conduction abnormalities, and high CSF protein level. Diabetes mellitus, monoclonal gammopathy, hepatitis C infection, HIV infection, SLE, Sjogren syndrome and lymphoma have been associated with CIDP. The incidence of CIDP in diabetes is not known exactly, but occur more common among diabetic than nondiabetic patients. There is sometimes a difficulty in distinguishing between diabetic polyneuropathy and CIDP, but differential diagnosis is important because CIDP is treatable with immune-modulating therapy. We report a case of CIDP in 22-year-old girl with type 1 DM who presented with generalized motor weakness and walking disturbance which were treated with iv immunoglobulin

Keyword

Chronic inflammatory demyelinating polyneuropathy; IV immunoglobulin; Type 1 DM

MeSH Terms

Diabetes Mellitus
Diabetic Neuropathies
Diagnosis, Differential
Female*
Hepatitis C
HIV Infections
Humans
Immunoglobulins
Incidence
Lymphoma
Muscles
Neural Conduction
Paraproteinemias
Polyneuropathies*
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
Reflex, Abnormal
Sjogren's Syndrome
Walking
Young Adult
Immunoglobulins

Figure

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  Fig. 1 General appearance of the patient. A: 2 years ago. before admission. B: At admission, she has weakness and atrophy of muscles in both extremities leading to walk disturbance.

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  Fig. 2 Pes cavus deformity with hammer toe.

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  Fig. 3 Diaphragmatic paralysis. There is little movement of the diaphragm between inspiration and expiration. A: full inspiration state. B: full expiration state.

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