Korean J Thorac Cardiovasc Surg.  1999 Apr;32(4):364-367.

Clinical Study of the Effect of Aprotinin for Hemostasis in Open Heart Surgery

• Jung SW
• Kim JW

Abstract

BACKGROUND: The efficacy of the hemostasis of prophylactic aprotinin after cardiac valve replacement was evaluated from January 1994 to December 1996 at Pusan National University Hospital. MATERIAL AND METHOD: In a randomized study, 20 patients received aprotinin(2x106 KIU as a loading dose for 30 minutes after anesthesia, 1x106 KIU for priming and 5x105 KIU/hr as a maintenance dose from the completion of loading dose till skin closure) and another 20 untreated patients served as controls. RESULT: Aprotinin produced a significant reduction in postoperative blood loss compared with controls and significantly decreased total exposure to allogenic blood products compared with the control group(p<0.05).
CONCLUSION
We conclude that aprotinin effectively reduces postoperative blood loss and trasfusion in patient undergoing cardiac valve replacement.

Keyword

Aprotinin; Hemostasis

MeSH Terms

Anesthesia
Aprotinin*
Busan
Heart Valves
Heart*
Hemostasis*
Humans
Postoperative Hemorrhage
Skin
Thoracic Surgery*
Aprotinin