The Effect of Electrohydraulic Shock Wave on Renal Parenchyme of White Rat

Lee, Sung Won; Kim, Si Whang

Abstract

An experimental study was performed for the observation of the effect of the shock wave on the renal parenchyme of the white rat. Sixty Sprague-Dawley rats were subjected to this study. The experimental rats were divided into four groups by the intensity and amount of shock wave and also each group was subdivided into three small groups by the time of sacrifice. The following results of gross and microscopic examination were obtained. After expulsion of shock wave, various injuries such as subcapsular hematoma, parenchymal hematoma and laceration were seen and the degree of injuries was increased according to the intensity and amount of shock wave macroscopically. On the 1st day of sacrifice, the ischemic necrosis of parenchyme was observed at directly exposed site, the hemorrhage, congestion and arteriolar damages at transitional zone. On the 7th day, the renal capsular thickening by fibroblast proliferation and focal fibrosis was appeared at direct zone. At transitional zone, moderate lymphocyte infiltration was observed. On the 28th day, renal parenchyme was replaced by fibrosis at direct zone, severe lymphocyte infiltration and thyroidaization were observed at transitional zone. The degree of injuries was not proportional to the amount and intensity of shock wave microscopically and the reasons will be discussed later. Conclusively, the shock wave caused the partial functional loss and pathologic sequela of renal parenchyme.