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Feasibility of artificial intelligence-based decision supporting system in tolvaptan prescription for autosomal dominant polycystic kidney disease

Shin JH, Kim YH, Lee MK, Min HS, Cho H, Kim H, Kim YC, Lee YS, Shin TY

Purpose: Total kidney volume (TKV) measurement is crucial for selecting treatment candidates in autosomal dominant polycystic kidney disease (ADPKD). We developed and investigated the performance of fully-automated 3D-volumetry model and...
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Rac1 inhibition protects the kidney against kidney ischemia/ reperfusion through the inhibition of macrophage migration

Park YR, Kong MJ, Noh MR, Park KM

Kidney ischemia/reperfusion (I/R) injury, a common cause of acute kidney injury (AKI), is associated with the migration of inflammatory cells into the kidney. Ras-related C3 botulinum toxin substrate 1 (Rac1),...
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Recent updates in therapeutic approach using tolvaptan for autosomal dominant polycystic kidney disease

Kim Y, Han S

As a genetic disease, there has been a long-standing effort to identify therapeutic options for autosomal dominant polycystic kidney disease (ADPKD). Following the development of tolvaptan, a vasopressin 2 receptor...
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Sarcopenia in chronic kidney disease: from bench to bedside

Kim DW, Song SH

Sarcopenia is a condition characterized by a loss of muscle mass and function. In chronic kidney disease (CKD), where a chronic catabolic state exists, sarcopenia commonly occurs through various mechanisms,...
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Long term renal outcome after hypertensive disease during pregnancy: a nationwide population-based study

Lee KH, Bae JH, Lee J, Jung YM, Park CW, Park JS, Jun JK, Cho GJ, Lee SM

Objective Hypertensive disease during pregnancy increases the risk of maternal morbidity and mortality and leads to the development of multi-organ dysfunction, including kidney dysfunction. Complicated pregnancies require careful postpartum management...
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Improvement of Dialysis Dosing Using Big Data Analytics

Mumtaz SL, Shamayleh A, Alshraideh H, Guella A

Objectives: Large amounts of healthcare data are now generated via patient health records, records of diagnosis and treatment, smart devices, and wearables. Extracting insights from such data can transform healthcare...
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Inhibition of Fatty Acid β-Oxidation by Fatty Acid Binding Protein 4 Induces Ferroptosis in HK2 Cells Under High Glucose Conditions

Chen J, Wu K, Lei Y, Huang M, Cheng L, Guan H, Lin J, Zhong M, Wang X, Zheng Z

Background: Ferroptosis, which is caused by an iron-dependent accumulation of lipid hydroperoxides, is a type of cell death linked to diabetic kidney disease (DKD). Previous research has shown that fatty...
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Evaluation of Vancomycin TDM Strategies: Prediction and Prevention of Kidney Injuries Based on Vancomycin TDM Results

Kim B, Hwang S, Heo E, Kim Hs, Jung J, Kim ES, Kim HB, Lee K, Park JS, Song J, Lee JH, Chung JY, Song KH, Yoon S

The current guidelines for therapeutic drug monitoring (TDM) of vancomycin suggest a target 24-hour area under the curve (AUC 0-24 ) of 400 to 600 mg*h/L for serious methicillinresistant Staphylococcus...
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Early Enteral Nutrition and Sepsis-Associated Acute Kidney Injury: A Propensity Score Matched Cohort Study Based on the MIMIC-III Database

Wang J, Jiang L, Ding S, He SY, Liu SB, Lu ZJ, Liu YZ, Hou LW, Wang BS, Zhang JB

Purpose: We aimed to analyze the optimal timing of enteral nutrition (EN) in the treatment of sepsis and its effect on sepsis-associated acute kidney injury (SA-AKI.) Materials and Methods: The...
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The relationship between long-term use of nonsteroidal anti-inflammatory drugs and kidney function in patients with ankylosing spondylitis

Koo BS, Hwang S, Park SY, Shin JH, Kim TH

Objective: Although nonsteroidal anti-inflammatory drugs (NSAIDs) are the first-line treatment for ankylosing spondylitis (AS), their effect on kidney function remains unclear. This longitudinal study investigated the correlation between long-term NSAID...
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Changes in Cardiac Structure and Function After Kidney Transplantation: A New Perspective Based on Strain Imaging

Kim D, Kim M, Park JB, Lee J, Huh KH, Hong GR, Ha JW, Choi JO, Shim CY

BACKGROUND: We aimed to investigate left ventricular (LV) global longitudinal strain (GLS) in end-stage renal disease patients and its change after kidney transplantation (KT). METHODS: We retrospectively reviewed patients who underwent...
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Impact of preoperative ultrasonography for predicting the prognosis of deceased donor kidney transplantation

Yun SO, Lee KW, Park JB, Kim MJ, Park SY, Park B

Purpose: This study evaluated the role of donor kidney ultrasonography (US) for predicting functional kidney volume and identifying ideal kidney grafts in deceased donor kidney transplantation. Methods: In total, 272 patients...
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Epidemiology of Urologic Cancer in Korea: Nationwide Trends in the Last 2 Decades

Han SH, Yuk HD

Purpose: This study assessed recent trends in the incidence of urologic cancer and patient survival in Korea. Materials and Methods: The incidence of urologic cancer in Korea was calculated based on...
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Delayed exacerbation of COVID-19 pneumonia in vaccinated kidney transplant recipients receiving immunosuppressants: a case series

Ryu TH, Kim HY, Ahn J, Oh JS, Kim JK

Coronavirus disease 2019 (COVID-19) increases the risk of mortality and hospitalization in immunocompromised patients, including kidney transplant recipients (KTRs) receiving immunosuppressants. Several vaccines for COVID-19 have been developed and proven...
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The first successful eculizumab rescue therapy of a kidney transplant recipient with atypical hemolytic uremic syndrome in South Korea: a case report

Min EK, Kim HJ, Kim S, Jung M, Kim JS, Han SH, Huh KH

Atypical hemolytic uremic syndrome (aHUS) is a form of thrombotic microangiopathy (TMA) that can result in end-stage renal disease. Patients with aHUS often have predisposing dysfunction in the complement pathway,...
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Different antibody responses between liver and kidney transplant recipients elicited by third doses of COVID-19 mRNA vaccines

Lim SY, Yoon YI, Kim JY, Tak E, Kwon H, Shin S, Kim YH, Song GW, Kim SH, Lee SG

Background: Solid organ transplant recipients exhibit decreased antibody responses, mainly due to their weakened immune systems. However, data are limited on antibody responses after the primary series of coronavirus disease...
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A systematic review and meta-analysis comparing everolimus and calcineurin inhibitors (CNIs) to mycophenolate and CNIs in kidney transplant patients

Vergara-Rejante L, Tanhui KK, Alolod MKL

Background: This study compared everolimus and mycophenolate mofetil, each paired with calcineurin inhibitors (CNIs) and used with or without steroids, for maintaining immunosuppression in kidney transplant (KT) patients. Methods: Relevant studies...
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Changes in socioeconomic status and patient outcomes in kidney transplantation recipients in South Korea

Park S, Park J, Jeong J, Jang Y, Kim YC, Kim DK, Oh KH, Joo KW, Kim YS, Lee H

Background: Socioeconomic status is an important factor affecting the accessibility and prognosis of kidney transplantation. We aimed to investigate changes in kidney transplant recipients’ socioeconomic status in South Korea and...
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Pretransplant C-reactive protein-to-albumin ratio predicts mortality in kidney transplant recipients: a retrospective cohort study

Kwon JW, Jeon Y, Jung HY, Choi JY, Park SH, Kim CD, Kim YL, Hwang D, Yun WS, Kim HK, Huh S, Yoo ES, Won DI, Cho JH, Lim JH

Background: The C-reactive protein (CRP)-to-albumin ratio (CAR) is a more effective prognostic indicator than CRP or albumin alone in various diseases. This study aimed to evaluate the predictive value of...
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Characteristics and management of thrombotic microangiopathy in kidney transplantation

Cho W, Jo SK, Jung CW, Kim MG

Thrombotic microangiopathy is not a rare complication of kidney transplantation and is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury with extensive thrombosis of the arterioles and capillaries....
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