A Clinical Observation on 29 Patients with Renal Cell Carcinoma

Chung, Sung Kwang; Chang, Sae Kook

Abstract

Renal cell carcinoma accounts for majority of all primary renal malignancies. Because of its unique clinical and biologic behavior, renal cell carcinoma has been considered the most interesting of human malignancies. A clinical observation was made on the 29 patients with renal cell carcinoma at the Department of Urology, Kyungpook National University Hospital during the period from January, 1975 to December 1981. The following results were obtained; 1. The most prevalent age group was sixth decade. Male to female ratio was 1.9:1. 2. The most frequent symptom and sign was palpable mass, present in 48%, but the classic triad of this tumor presented in 31%. 3. Para neoplastic syndromes associated with renal cell carcinoma were seen, with elevated ESR in 79%, severe anemia in 38%, and reversed A/G ratio without hepatic metastasis in 28%, in order of frequency. 4. On the urogram enlarged kidney was found in 72%, renal mass in 48%, calyceal destruction in 48%, and nonvisualization of kidney in 21% in order of frequency. 5. The angiogram of 18 patients demonstrated hypervascular tumor in 16 and hypovascular tumor in 2 patients. 6. Pathologic staging revealed stage I in 2, stage II in 5, stage III in 5, and stage IV in 8 of 21 patients. 7. Histologically clear cells were predominated in 12 and granular cells in 6 patients. And mixed cell type was observed in 3 patients. 8. Simple nephrectomy was performed in 4 patients, radical nephrectomy in 16 patients, and pedicle ligation only in 1 patient. Combined treatment with surgery and adjuvant therapy was undergone in 6 patients.