Genomics Inform.
2011 Jun;9(2):59-63.
Lack of Replication of Genetic Association with Body Mass Index Detected by Genome-wide Association Study
- Affiliations
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- 1Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul 138-736, Korea. cookie_jklee@hotmail.com
- 2Department of Statistics, College of Natural Science, Seoul National University, Seoul 110-744, Korea.
- 3Department of Statistics, Sookmyung Women's University, Seoul 140-742, Korea.
- 4DNA Link, Seoul 121-850, Korea.
- 5Center for Genome Science, National Institute of Health, Chungwon 363-951, Korea.
Abstract
- Obesity provokes many serious human diseases, including various cardiovascular diseases and diabetes. Body mass index (BMI) is a highly heritable trait that is broadly used to diagnose obesity. To identify genetic loci associated with obesity in Asians, we conducted a genome-wide association study (GWAS) of a population of Korean adults (n=6,742, age 40~60 years) and detected six BMI risk loci (TNR, FAM124B, RGS12, NFE2L3, MC4R and FTO) having p<1x10(-5). However, in the replication study, only melanocortin 4 receptor gene (MC4R) (rs9946888, p=4.58x10(-7)) was replicated with marginal significance (p<0.05) in the second cohort (n=5,102, age 40~60 years). This study indicates that each locus associated with BMI has very weak genetic effect.
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