J Korean Neuropsychiatr Assoc.
2011 Jan;50(1):20-38.
Genome-Wide Association Study in Psychiatric Disorders
- Affiliations
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- 1Department of Psychiatry, Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Korea. kimsejoo@yuhs.ac
- 2Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Abstract
- Most psychiatric disorders are some kinds of complex genetic traits. Identifying the causal genes of psychiatric disorders has been challenging. Through recent revolutionary advances, such as the HapMap Project and the development of high-throughput genotyping chips, the genome-wide association study (GWAS) has recently become possible and is now in the spotlight in psychiatric genetics. In this article, we reviewed the concepts, rationale, designs and general steps of GWAS, and also introduced a few previous GWAS of several psychiatric disorders.
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