Mycobiology.  2008 Mar;36(1):66-69. 10.4489/MYCO.2008.36.1.066.

Simple Method of Preparation and Characterization of New Antifungal Active Biginelli Type Heterocyclic Compounds

• Pothiraj C
• Velan AS
• Joseph J
• Raman N

• KMID: 2052891
• DOI: http://doi.org/10.4489/MYCO.2008.36.1.066

Abstract

A simple, efficient and cost effective method is described for the synthesis of Biginelli type heterocyclic compounds of dihydropyrimidinones analogous. They were prepared from a reaction mixture consisting of substituted benzaldehydes, thiourea and ethylacetoacetate using ammonium dihydrogenphosphate as catalyst. The procedure for the preparation of the compounds is environmentally benign and safe which is advantageous in terms of experimentation, catalyst reusability, yields of the products, shorter reaction times and preclusion of toxic solvents. The four new synthesised compounds were tested for their antifungal activity. They have good antifungal activity comparing to the standard (Fluconazole).

Keyword

Antifungal; Biginelli reaction; Dihydropyrimidinones; Ethylacetoacetate; Heterocyclic compounds; Thiourea

MeSH Terms

Benzaldehydes
Heterocyclic Compounds
Quaternary Ammonium Compounds
Reaction Time
Solvents
Thiourea
Benzaldehydes
Heterocyclic Compounds
Quaternary Ammonium Compounds
Solvents
Thiourea